Supplementation for the gut-brain connection

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The gut-brain connection plays a pivotal role in regulating your mood, digestion, and overall well-being. While a balanced diet is essential, certain supplements can provide extra support to optimize this crucial link between your gut and brain. Here are a few key supplements that may help enhance your gut-brain axis.

1. Probiotics

Probiotics are beneficial bacteria that help balance the gut microbiome. Research suggests that probiotics can positively influence mood, reduce symptoms of anxiety and depression, and improve gut health. Look for a high-quality multistrain probiotic to support a diverse gut microbiome.

2. Prebiotics

Prebiotics are fibers that feed healthy gut bacteria, promoting a thriving microbiome. Inulin, fructooligosaccharides (FOS), and galactooligosaccharides (GOS) are common prebiotics that support gut health and can enhance mental clarity. Prebiotic supplements or prebiotic-rich foods like fiber-rich vegetables can benefit both your digestive system and brain function.

3. Omega-3 Fatty Acids

Omega-3 fatty acids, particularly DHA and EPA, are essential for brain health and inflammation control. Found in fish oil or algal oil, omega-3s have been shown to improve mood, reduce brain inflammation, and support cognitive function. They also promote gut health by reducing inflammation in the gut lining.

4. Magnesium

Magnesium plays a vital role in regulating the nervous system and promoting relaxation. It helps manage stress, improves sleep quality, and supports gut motility. Magnesium supplements can help reduce symptoms of anxiety, muscle tension, and digestive discomfort. Opt for magnesium glycinate for better absorption and fewer digestive side effects.

5. L-Glutamine

L-Glutamine is an amino acid that helps repair the intestinal lining and promote gut health. It’s particularly beneficial for individuals with leaky gut or digestive issues. L-Glutamine supports the gut barrier, preventing harmful substances from entering the bloodstream and impacting both digestion and mental clarity.

While lifestyle changes like stress management and diet are crucial for gut-brain health, targeted supplementation can offer additional support. By incorporating probiotics, omega-3s, magnesium, and other gut-supportive supplements, you can help nurture the gut-brain connection and improve both mental and digestive health. Always consult with a healthcare provider before starting any new supplement to ensure it's right for you.

Interested in learning more about the gut-brain connection?

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Published: June 2nd, 2025

This blog post was written by Amanda Sikkema, a dietitian at Katie Chapmon Nutrition. Amanda works with clients virtually and is accepting new clients.

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Lifestyle for the gut-brain connection